Endocrine Abstracts

Background: Parathyroid carcinoma (PC) is uncommon and occurs in only 1–5% cases of primary hyperparathyroidism. The histological diagnosis of parathyroid tumors can be challenging, and beneficial histological markers are not available for diagnosis or predicting the prognosis of patients. In this study, we investigated the expression of Ki-67, parafibromin, p27, and Rb protein in parathyroid tumors and assessed the correlation between histological diagnosis or prognosis,...

Context: Prior to thyroidectomy for Graves’ disease, thyroid function should be adequately controlled to avoid complications such as thyroid storm. However, preoperative thyroid function control is sometimes difficult.Objective: This study assessed the postoperative risks are increased or not if biochemically hyperthyroid patients undergoing total thyroidectomy in comparison to euthyroid patients.Methods: A retrospective, coho...

Background: Graves’ hyperthyroidism is known to improve spontaneously during pregnancy due to immune tolerance, although postpartum worsening or relapse of hyperthyroidism is likely to occur.Objective: To investigate the prevalence of postpartum worsening of Graves’ orbitopathy (GO) in relation to thyroid dysfunction.Methods: This was a retrospective cross-sectional study that included 8594 patients with Graves’ dise...

Objective: Appropriate administration of anti-inflammatory and immunosuppressive treatment (AIIST) is still important for patients with Graves’ orbitopathy (GO). This study aimed to clarify the incidence of and risk factors for GO treated with AIIST, among newly diagnosed Graves’ disease (GD) patients in Japan.Methods: A total of 1558 GD patients who were newly diagnosed at Ito Hospital during the year 2011 were investigated. AIIST included loc...

Background: Papillary thyroid microcarcinoma (PTMC) has low malignant potential and an extremely good prognosis. However, surgical findings of asymptomatic PTC, can occasionally reveal tumor invasion into the recurrent laryngeal nerve (RLN). The present study assessed the feasibility of evaluating tumor invasion into the RLN using ultrasonography (US) and computed tomography(CT).Materials and methods: Of 7,916 patients with a PTC who underwent surgery at...